Why are Lysobact® products unique?

In the market of B&H and the region, only Lysobact® products contain lysozyme!

Lysobact® products act on the causes of inflammation of the mouth and throat, alleviate inflammation and its symptoms, accelerate healing, and can prevent the development of more severe infections and inflammation.

Due to its natural ingredients, Lysobact® is one of the safest drugs in its group.

Lysobact® is one of the most used products in the treatment of inflammation of the mucous membranes of the mouth and throat. To date, Lysobact® has been used by more than 50 million people worldwide.

 

About lysozyme in Lysobact® products:

Lysozyme is a basic protein of natural origin with enzymatic action that performs various useful functions in the body. The ability of lysozyme to destroy (“lysis”, Greek  λύσις) bacterial cells became the root of his name. Lysozyme was discovered in 1922 by Nobel laureate Alexander Fleming.

It is normally present in saliva, blood, tears, breast milk / colostrum, gastric contents and digestive juices, urine, sweat… and in many human cells that are part of the immune system, such as e.g., neutrophilic leukocytes, reticuloendothelial cells, monocytes, and macrophages, so-called Kupffer cells …

Since the mouth is the “entrance door” for microorganisms from the external environment, lysozyme in the saliva represents the first line of defense of the organism, preventing the penetration of microorganisms.

Clinical studies confirm that lysozyme acts:

–  antimicrobial   (against bacteria, viruses, and fungi). Antibacterial properties are reflected in the ability of lysozyme to destroy bacteria.  At least six different mechanisms have been identified by which lysozyme destroys various bacteria. In early research, the following bacterial species showed sensitivity to the action of lysozyme:   Micrococcus, Sarcina, Staphylococcus, Streptococcus, Lactobacillus, Bifidobacterium,  Bacillus, Clostridium, Corynebacterium, Escherichia, Salmonella, Shigella, Erwinia, Yersinia, Pseudomonas, Pasteurella, Neisseria, Campylobacter  etc.

Lysozyme also works against some viruses like Herpes simplex and Herpes zoster, as well as virus Influenzae (influenza virus), as well as against some fungi from the genera  Candida, Phytophtora and Fusarium.

In combination with antimicrobials, lysozyme enhances their action (e.g., enhances the action of antibiotics on bacteria).

–  anti-inflammatory. Lysozyme reduces inflammation by affecting the inflammatory process in the mucous membranes of the mouth and throat, which can be caused by microorganisms, but also by physical and chemical factors (e.g. dentures or covers, sudden changes in air temperature, dry air, talking too loud or too long, dust, cigarette smoke), alcohol, hot or spicy foods, hot or carbonated beverages…), as well as due to decreased immunity (e.g. the formation of canker sores, which can then be secondarily infected with bacteria, viruses and fungi). Lysozyme stabilizes the membranes of inflamed cells and prevents excessive activation and reduces the destructive activity of some inflammatory enzymes. The anti-inflammatory action of lysozyme leads to a mild analgesic effect (acts against pain).

–  proregenerative,  i.e., helps and accelerates the regeneration (renewal and healing) of the mucosa. Lysozyme has a positive effect on tissue regeneration after inflammation, injury, or surgery. By reducing the accumulation of inflammatory cells and stimulating the cells that participate in the process of wound healing and damage to the mucous membrane of the oral cavity, lysozyme helps and accelerates these useful processes.

In children with a reduced concentration of lysozyme in the oral cavity, stronger symptoms of inflammation and slower healing of the postoperative wound after tonsillectomy (“tonsillectomy”) are observed.

–  immunomodulatory, i.e. lysozyme strengthens the local immune response of the oral mucosa, stimulates beneficial immune responses (stimulates immune system cells to produce substances such as interferon, interleukin, tumor necrosis factor, promotes coordinated local action of immune system cells) and reduces harmful or excessive inflammatory membranes cells and reduces their degranulation and release of mediators of inflammatory and allergic reactions, is involved in “cleansing” the body of harmful components of the immune response). Lysozyme also prevents the formation of so-called. free radicals or acts as an antioxidant.

–  mucoprotective. Lysozyme is one of the most important factors in strengthening the nonspecific local resistance of the mucous membranes of the mouth and throat. Lysozyme protects the mucosa by increasing its non-specific resistance to infections.  Lysozyme shows the ability of bacteria to aggregate, which reduces the ability of bacteria to adhere and colonize surfaces in the mouth and improves their removal from the oral cavity.  Lysozyme enhances both the adhesive and antimicrobial properties of Ig A (immunoglobulin A).

Lysozyme prevents the imbalance of the normal bacterial flora in the mouth. Decreased concentration of lysozyme in the oral cavity is found in children with chronic tonsillitis (chronic tonsillitis).

–  antiallergic. The action of lysozyme reduces the so-called antigenic load on the body (antigens are molecules that stimulate the body’s immune response and if they are found in so-called allergens, they can cause excessive and violent immune reactions in hypersensitive people, which we call allergies). By stimulating phagocytosis and enhancing the cooperative functions of lymphocytes, lysozyme contributes to the recognition of harmful antigens and prevents their penetration into the body.

– „anti-plaque“ acting.  Lysozyme has been shown to reduce the accumulation of dental plaque. Lysozyme is important in the prevention of dental caries.

Due to all the listed properties, lysozyme is widely used in the world for various preventive and therapeutic purposes.

 

About other ingredients in Lysobact® products:

Vitamin B6

Pyridoxine is a vitamin from the group of B vitamins that shows a protective effect on the mucous membrane of the oral cavity.  It achieves a protective effect by preventing the integrity of the cells of the oral mucosa from being disturbed.  It also has a supportive metabolic role by acting as a coenzyme in the metabolism of proteins, carbohydrates, fats and steroid hormones.  It also has a certain effect against the formation of canker sores and contributes to their faster disappearance.

Cetylpyridine

Cetylpyrirdine is an antimicrobial antiseptic that enhances the antibacterial action of lysozyme.  It shows a wide antimicrobial spectrum of action against many microorganisms, including viruses and fungi. Even in the case of relatively long-term use of cetylpyridine, the balance of the oral flora is not disturbed. The safety of topical administration of cetylpyridine in the oral cavity, within the recommended doses, has been evaluated in detail and confirmed in various controlled clinical and preclinical studies.

Lidocaine

Lidocaine is a local anesthetic that gently anesthetizes the mucous membranes of the mouth and throat, thus eliminating the feeling of pain that is an accompanying symptom of all the stronger inflammatory processes in the mucous membranes of the mouth and throat.

 

Table 1 Comparative review of useful preventive-therapeutic actions in the oral cavity and throat

Useful actions Lysobact®
Lysobact P Spray®
Lysobact DUO® i Lysobact Spray® Lysobact Complete Spray® Other oral antiseptics on the market
antimicrobial YES YES* YES* YES
analgesic YES YES YES NO/YES
anesthetic NO NO YES NO/YES
anti-inflammatory YES YES YES NO
proregenerative YES YES YES NO
mucoprotective YES YES YES NO
immunomodulatory YES YES YES NO
antiallergic YES YES YES NO
anti-plaque acting YES YES YES NO
Note It contains lysozyme and vitamin B6 Contains lysozyme and cetylpyridine. It contains lysozyme and cetylpyridine and lidocaine. They do not contain lysozyme

* Joint, synergistic antimicrobial activity of lysozyme and antiseptic cetylipyridine

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